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| The vibration, which has a frequency of 1,000 times per second, is thought to promote bone formation by encouraging signals between bone cells. In the lab, the stem cells are about 5-30 nanometers apart when they receive their nanokicking at 1,000 times per second. An Unlikely Match: Cell Biologists and Astrophysicists To deliver the nanokick precisely and at the right frequency, the researchers use an incredibly precise technique called laser interferometry, which is more commonly seen in the astrophysic lab to detect tiny ripples made by gravitational waves in space-time. In a remarkable example of collaboration between widely different disciplines, Dalby and fellow cell engineer Adam Curtis, also of the University of Glasgow, worked with astrophysicist Stuart Reid from the University of the West of Scotland's Thin Film Centre to adapt the laser interferometer for the study. Reid explains: Linking stem cell research with expertise from the field of gravitational wave astronomy, where we have developed instrumentation that can measure length changes almost million times smaller than the diameter of a proton, have enabled this unique research field to emerge. Dalby adds: Multidisciplinary research is tricky as researchers need to learn new scientific languages, however, this collaboration between cell biologists and astrophysicists - an unlikely pairing - has yielded new insight as to how bone stem cells work. Next Steps: Collaboration with Rehabilitation Engineers and Working with Patients The researchers hope their new technique will herald a fundamental change in the way we grow new bone. They are now planning to work with rehabilitation engineers in the Queen Elizabeth National Spinal Injuries Unit (Southern General Hospital, Glasgow) to help patients with spinal injuries. The vibration therapy techniques that Dalby and colleagues have developed in the lab now have to be scaled up and tested in patients to assess how well they stimulate new bone growth in whole bones.
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In their study conclusions they don't appear to see the upscaling as a huge problem: It is easy to envisage such stimulation protocols being up-scaled to form large-scale osteoblast bioreactors as standard cell culture plates and incubators are used in the protocol. We look forwards to working with the rehabilitation engineers; this will provide us with new challenges, but challenges that we welcome, says Dalby. In June 2012, US scientists writing in Stem Cells Translational Medicine, describe how they found a way to grow new bone using fresh, purified mesenchymal stem cells from fat tissue. Written by Catharine Paddock PhD A study that used secret shopper techniques to find out the price of a hip replacement in hospitals across the US finds a huge variation in price, by as much as a factor of ten, with many hospitals contacted not able to give an estimated price. Reporting in the 11 Feburary online issue of JAMA Internal Medicine, researchers at the University of Iowa (UI) Health Care and Iowa City VA Medical Center say their findings highlight the difficulties American consumers face when trying to obtain prices for a common surgical procedure. Consumers can get their hands on information about hospital quality reasonably easily in the US, but information on pricing is much harder to come by, according to the study, which suggests efforts to achieve greater transparency in pricing have largely been ineffective. Lead author Jaime Rosenthal says in a statement: There have been many initiatives to increase pricing transparency, including state and federal laws, and still many hospitals are unable to provide price information for a common procedure.
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